About ACC

What is Adenoid Cystic Carcinoma?
Adenoid Cystic Carcinoma is a very rare cancer typically originating in the salivary glands although it does appear in other primary sites, including the palate, nasopharynx, tongue base, larynx, trachea, breast and uterus. Its course is slow but persistent with frequent recurrences and metastases to the lungs, liver and bones. ACC has no known causes or links to smoking and alcohol consumption. It is slightly more prevalent in women than men.

What are the signs and symptoms?
Signs and symptoms largely depend on the site of origin of the tumor. Early lesions of the salivary glands present as painless masses of the mouth or face, usually growing slowly. Advanced tumors may present with pain and/or nerve paralysis. Tumors of the lacrimal gland may present as proptosis (“bulging eyes”) and changes in vision. ACC arising in the tracheobronchial tree may present with respiratory symptoms, while tumors arising in the larynx may lead to changes in speech.

How is the diagnosis made?
The diagnosis is made by histologic analysis of a biopsy of a tumor mass. There are no blood tests to detect this type of cancer.

What is the treatment for ACC?
Surgical resection, whenever possible, is the mainstay therapy. There is no effective chemotherapy for metastatic and/or unresectable ACC. Several clinical trials are examining the effects of relatively new chemotherapeutic drugs alone, or in combination with other drugs, in the control of metastatic or locally recurrent ACC.

Form more information, visit the Adenoid Cystic Carcinoma Research Foundation website: www.accrf.org.

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